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Pepcid Complete is an over the counter acid reflux medicine, combining two proven active ingredients in one drug – antacids (magnesium hydroxide and calcium carbonate)and acid reducer (famotidine). Some of the side effects and adverse reactions that people experience after taking Pepcid are: Nausea. It was one of the top-selling drugs in the US in 2016. Pepcid has an average rating of 6. The over the counter PPI’s are Tagamet HB, Pepcid AC, Axid, and Zantac From the #1 doctor recommended acid reducer brand, PEPCID COMPLETE ® is a chewable tablet that provides dual action heartburn relief that works fast and lasts. It is used to treat syndromes caused by lots of stomach acid. The product is licensed for the short-term relief of heartburn, dyspepsia and excess acid. It combines an antacid that starts neutralizing acid in seconds with an H2 blocker, famotidine, that helps control acid all day or all night. It is used to treat gastroesophageal reflux disease ( GERD; acid reflux ). 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